Nottingham: A mutated gene that helps control body weight may help fight obesity, scientists say.
The ZFHX3 gene variant (which is thought to affect only four percent of people who drink) has been found in research to control parts of the brain that are responsible for hunger.
Scientists from Nottingham Trent University and MRC Harwell have discovered a system in mice in which mutated genes alter appetite, weight and the hormone insulin (which controls blood sugar levels and diabetes). (prevents complications) plays an important role in controlling
In the research, the team found that this gene affects a part of the brain called the hypothalamus (the part that controls hunger, thirst and food intake) by turning on or off the action of other genes in the area.
Understanding this mechanism could pave the way for new weight loss therapies, the researchers said.
Researcher Dr Rebecca Dumbell from Nottingham Trent University said: “For the first time, scientists have shown this gene alters the protein’s growth and energy balance, similar to a variant found in extremely rare individuals. Is.
They said there is a large genetic component to our appetite and growth that is not fully understood.
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