The team of American expert Ali Madani under AI program created proteins that were bactericidal and some of them proved to be effective against E.coli bacteria in the laboratory. Photo: File
San Jose, California: For the first time, with the help of artificial intelligence, it was asked to create a useful protein that can destroy dangerous bacteria. Thus, when the software-designed protein was tested in the laboratory, it successfully destroyed many bacteria.
This work has been done under the supervision of Dr. Ali Madani who has established a biotechnology company called ‘Profluent’ after his PhD from America. With the help of Artificial Intelligence (AI), they have created not one but millions of new proteins and they were designed from the ground up. Looking at the properties of some of these proteins, they developed them and tested them in a real environment.
It should be noted that an AI program that writes text is ‘Progen’ which works exactly like a protein software. Because this program creates new proteins by amino acid sequence and contains data for more than 200 million proteins. However, experts instructed the software to now make proteins that could kill the bacteria.
Then the next step is to design the exact molecules of real cells. In the first step, 100 molecules were created realistically in the laboratory. 66 of these molecules played an important role in chemical reactions capable of killing bacteria in saliva and egg whites. This led to hope that it might now kill real and live bacteria as well.
Then the experts created five proteins that were highly active and when they were exposed to the famous and dangerous bacteria ‘E.coli’, two of them destroyed it.
The scientists then took X-rays of all the molecules and found that their amino acids were 30 percent different than real-world proteins, but the appearance was identical. Interestingly, molecules for medicine can be made in the same way, but it can take some time.
In summary, artificial intelligence can not only design therapeutic proteins but also facilitate drug development, however this may take some time.
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