Michigan: Researchers have made an important discovery in the treatment of prostate cancer that could make the aggressive form of the cancer curable.
According to media reports, a team of researchers led by Dr. Joshi Alumkal of the University of Michigan Rogel Cancer Center has identified a protein that transforms the early form of prostate cancer into an aggressive form.
Researchers have identified a protein called lysine specific demethylase 1 (LSD1) that makes an easy and treatable stage of prostate cancer more difficult.
Well, most prostate cancers are curable, but if they become more dangerous over time, treatment becomes difficult, which is called neuroendocrine prostate cancer.
Previous research by Dr. Joshi’s team found that the LSD1 protein plays a role in keeping prostate tumors alive by activating genes associated with stem cells, but the latest research extends the previous findings. suggests that LSD1 also plays a direct functional role in neuroendocrine prostate cancer.
They identified the effect of the LSD1 protein on the gene p53, which helps prevent tumor spread. The researchers found that the LSD1 gene inactivates p53, so if LSD1 itself is blocked from functioning, p53 can be reactivated and tumor growth inhibited.
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